Spear each grape with a toothpick. Set aside.
Microwave caramels and cream in small microwavable bowl on HIGH 2 minutes or until caramels are completely melted, stirring after every 30 seconds.
Dip each grape into melted caramel, allowing excess caramel to drip off. Place grapes on wax paper-lined tray. Sprinkle lightly with sea salt grinder. Refrigerate until caramel is set.