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Place 1/2 of the brisket and onion wedges in slow cooker.
Mix Seasoning, beer, chili sauce and brown sugar until blended. Pour 1/2 of the mixture over brisket. Top with remaining brisket and seasoning mixture. Cover.
Cook 8 hours on LOW or 4 hours on HIGH.
Remove brisket to serving platter. Slice thinly across the grain. Stir sauce before serving. Serve with brisket.