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Preheat oven to 350°F. Arrange opened Cooking Bag in 13x9-inch baking pan or dish. Place brisket in bag.
Sprinkle Seasoning Mix over meat. Add vinegar and water to bag. Close bag loosely with nylon tie. Cut 4 small holes in top of bag to allow steam to escape.
Bake in lower half of oven 2 hours. Let stand 5 minutes before slicing. Serve pan juices over brisket or thickened for gravy.