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Preheat oven to 350°F. Mix ground beef, 1 cup of the cheese, bread crumbs, egg, onion powder, garlic powder, pepper and salt in large bowl.
Shape into a loaf on shallow baking pan. Mix tomato sauce, basil and oregano. Pour over top.
Bake 55 to 60 minutes or until meat loaf is cooked through. Sprinkle top with remaining 1 cup cheese and pepperoni. Bake 10 to 15 minutes longer or until meat loaf is cooked through. Let stand 5 minutes before serving.