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Gently knead beef, garlic powder, salt and pepper in a bowl to combine. Divide the mixture into 4 equal portions and form them into 4-inch patties.
Heat a large cast-iron or regular skillet over medium-high heat. Reduce heat to medium and cook the burgers, turning once, until an instant-read thermometer inserted in the center reaches 165°F, about 10 minutes total. (Resist pressing them with your spatula so you don’t squeeze out all the juice and end up with dry burgers.)
Serve on a bun topped with about 1/2 cup chili and onion.