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To prepare barbecue sauce: Combine ketchup, beer, molasses, orange juice, vinegar, Worcestershire, mustard and onion powder in a medium heavy saucepan; bring to a simmer over medium-high heat, stirring. Reduce heat to maintain a simmer and cook, stirring frequently, until reduced to about 1 1/2 cups, 20 to 25 minutes. Stir in hot sauce.
To prepare chicken: Preheat a gas grill to medium or build a fire in a charcoal grill and let it burn down to medium heat (about 400°F).
Combine chicken with oil in a large bowl. Season with salt and pepper.
Oil the grill rack. Grill the chicken, with the lid closed, until lightly browned on the bottom, 10 to 12 minutes. Turn the chicken over, close the lid and grill for 10 to 12 minutes more. Brush the top of the chicken with about 1/2 cup of the barbecue sauce and grill for about 2 minutes. Turn over, brush the second side with another 1/2 cup of the sauce and continue grilling until an instant-read thermometer inserted into the thickest portion of the chicken registers 165°F, 2 to 4 minutes more. Serve the chicken with more barbecue sauce on the side, if desired.