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Rinse beans. Combine with 4 cups of the water in a Dutch oven. Bring to boiling; reduce heat. Simmer 2 minutes. Remove from heat. Cover; let stand 1 hour. (Or, place beans and 4 cups water in a large bowl; cover. Set in a cool place 6 to 8 hours.)
Drain beans and rinse. Return to pan. Add remaining 4 cups water and ham hocks. Stir in Worcestershire sauce, liquid smoke (if desired), onion, garlic powder, chili powder, jalapeno pepper and pepper sauce.
Bring to boiling; reduce heat. Cover and simmer 2 1/2 hours or until beans are tender. Add more water, if necessary, and stir occasionally. Add barbecue sauce to taste during last 5 to 10 minutes of cooking, if desired. Remove pork hocks; remove meat from bones and discard bones. Chop meat and stir into beans.